A unique course that connects three diverse fields using the unifying concept of a state-space with 2^N dimensions defined by N binary bits. We start from the seminal concepts of statistical mechanics like entropy, free energy and the law of equilibrium that have been developed with the purpose of describing interacting systems occurring in nature. We then move to the concept of Boltzmann machines (BM) which are interacting systems cleverly engineered to solve important problems in machine learning. Finally, we move to engineered quantum systems stressing the phenomenon of quantum interference which can lead to awesome computing power.